Toolbox

Allometric Scaling

To predict human plasma clearance

This application will predict human plasma clearance from plasma clearance observed in animal species according to the relationship between bodyweight and metabolic parameters1:

y = a[Body Weight]b

Various studies have shown that the best predictions are achieved when pharmacokinetics are obtained from at least three species3. If you have pharmacokinetic parameters in monkey, predictions at least as good if not better can be obtained by correcting monkey clearance for liver blood flows in monkey and human5, so this will be calculated also if you select monkey from the lists below.

So, select three species from the drop-down lists in order of increasing body weight:

 


For references see the report at the end of the application.